Vancogenx®-Space Knee is the preformed spacer for knee preloaded with Gentamicin and Vancomycin. The device is made with antibiotic loaded bone cement and it’s made of two independent articulating components. It’s available in 4 different sizes (Small, Medium, Large, Extra Large).
The most studied preformed spacer
Tecres spacers represent today the most studied and published spacer devices with over 131 publications in peer-reviewed journals.
High success rate
The relevant clinical information extracted from 37 peer-reviewed papers (30 different hospitals, more than 1,600 unique patients) shows that the infection eradication rate, at a mean follow-up of 56 months, exceeds 91%.
Antibiotics synergy
When combined, Gentamicin and Vancomycin have a synergistic action against bacteria.1-2-3 Their range of action covers approximately 90% of the pathogenic agents generally isolated in surgical infections.3-4 The Gentamicin and Vancomycin combination is the most commonly used and published combination in cases of concomitant treatment of orthopaedic infections. 5-6-7
Preformed, safe and reliable
The use of a preformed commercial spacer, with standardized mechanical and pharmacological properties is an option which provides mechanical, biological and pharmacological safety and performance.
Advantages
- maintain the correct joint space
- allow a good range of joint mobility
- promote early rehabilitation by providing a means to avoid muscular retraction
- allow the patient greater function during the treatment period
- allow partial weight-bearing with crutches when the residual bone stock is adequate
- provide high and inhibitory local concentration of antibiotic in the site of infection at implantation (Bertazzoni Minelli et al., 2015) which is maintained over time (Mutimer et al., 2009).
Bibliography – 1. Watanakunakorn C, et al. Antimicrob Agents Chemother. 1973; 2. Watanakunakorn C, et al. Antimicrob Agents Chemother. 1982; 3. E. Bertazzoni Minelli, et al. Anaerobe. 2011; 4. Trampuz A, et al. Swiss Med Wkly. 2005 ; 5. Penner MJ, et al. J Arthroplasty. 1996; 6. Masri BA, et al. J Arthroplasty. 1998; 7. Bertazzoni Minelli E, et al. J Chemother. 2002
